Document Details

Document Type : Article In Journal 
Document Title :
Synthesis and 1H NMR Spectroscopic Studies of PartiallyDeuterated N-Propionyl Derivative of Chiral Auxiliary Chiracamphox Spiro?Oxazolidin-2-One
بروبيونايل المستبدل جزئيا بالديوتيريوم لمركب كيرالي مساعد ( Chiracamphox ) سبيرو - اوكسازوليدين - 2 -ون الطيفية لمشتق N-1H NMR تحضير ودراسات
 
Subject : physical Sciences 
Document Language : English 
Abstract : In order to distinguish between the prochiral methylene protons HA and HB in the N-propionyl derivative of the chiral auxiliary spiro-oxazolidin-2-one, the partially deuteration of one of these two protons was employed. A new method was employed for synthesis of the N-propionate partially deuterated derivative using lithium di-isopropyl amide (LDA) to form lithium enolate which was treated with AcOD to yield non-isolated mixture of both the N-propionyl derivative and its partially deuterated derivative. 1H NMR studies of the product revealed that the partially deuteration was occurred and confirmed that the two diastereotopic protons HA and HB are distinguishable. 
ISSN : 1012-1319 
Journal Name : Science Journal 
Volume : 14 
Issue Number : 1 
Publishing Year : 1422 AH
2002 AD 
Number Of Pages : 6 
Article Type : Article 
Added Date : Sunday, October 11, 2009 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
طارق ر. صبحيTARIQ R. SOBAHIResearcher  

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