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Document Type |
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Article In Journal |
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Document Title |
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Effect of Tamoxifen on the Level of the Gonadotrophins, Estrogenand Progesterone Hormones pre and post Implantation in the Rats تأثير التماكسوفين على مستوى الهرمونات التناسلية وهرمون الأسترجين والبروجسترون قبل وبعد انغراس الاجنة في الجرذان |
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Subject |
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Biological Sciences |
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Document Language |
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English |
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Abstract |
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Tamoxifen was given orally to two groups of pregnant female
rats (0.4 mg/kg/day). First group before implantation ?(day 1-3
post coitus), and the second after implantation (day -7-9 post coitus)
with a control group given a saline only. After the last day of treatment
blood samples were collected from the eye blood vessel of the
females. The analysis of the gonadotrophin hormones (FSH, LH) and
the sex hormones (Progesterone and Estrogen) were done by hormones
kit. In both female groups (before and after implantation) the
level of (FSH) was significantly decreased (P < 0.001; 4.22. ± 0.76 µl/
ml and p < 0.05; 1.79 ± 0.38 mlµ/ml respectively) as compared to the
control group (16.11 ± 2.26 mlµ/ml and 3.28 ± 0.34 before and after
implantation respectively). While in the second group (post implantation)
there were no significant effects of tamoxifen treatment on the
levels of other hormones between both treated and control groups.
There were some changes in hormone levels between the pre and post
implantation, except the estrogen remain at the same level in all
groups. The study indicates that tamoxifen acts differently (directly or
indirectly) at the level of sex or gonadotrophin hormones. |
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ISSN |
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1012-1319 |
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Journal Name |
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Science Journal |
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Volume |
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17 |
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Issue Number |
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1 |
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Publishing Year |
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1425 AH
2005 AD |
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Number Of Pages |
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7 |
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Article Type |
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Article |
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Added Date |
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Sunday, October 11, 2009 |
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