Document Details

Document Type : Article In Journal 
Document Title :
Genotype at the Aldose Reductase Locus Affects Retinopathy-Free Survival in Type I Diabetes
اعتلال الشبكية لمرضى السكري اليافعين تختلف على حسب الأَلائِلِ السَّائِلَةِ المِكْرَوِيَّةِ لِمُخْتَزِلَةِ الأَلْدُوز
 
Subject : Original Articles 
Document Language : Arabic 
Abstract : The aim of this study is to examine whether the retinopathy-free survival in diabetics is linked to the genotype at the Adose Reductase Locus. Two hundred and fifty-six Australian adolescents with type 1 diabetes were attending for complication, screenings were genotyped. One microsatellite at the aldose reductase was amplified by Polymerase chain reaction to produce fragments of 126-152 base pair (Z = 138). Kaplan-Meier survival analysis was used to determine the duration free of retinopathy according to genotypes Z-2/Z-2, Z-2/non Z-2 and non Z-2/non Z-2. A stereoscopic fundal photography was performed; blinded to the patients' genotype. The presence of a background retinopathy was defined as any microaneurysm or hemorrhage. The results of our study show that, Median survival free of retinopathy was significantly shorter in patients having the Z-2 allele (p = 0.014). When survival analysis was performed on combinations of both Z-2 and Z+2, the only significant difference was between Z+2/non Z+2 and non Z+2/non Z+2 (p = 0.04). We concluded that survival free of retinopathy was significantly reduced in Australian patients with a Z-2 allele with less evidence for other alleles. This may represent that some sort of protective mechanism of retinopathy in patients with absent Z-2 allele. 
ISSN : 1319-1004 
Journal Name : Medical Science Journal 
Volume : 15 
Issue Number : 4 
Publishing Year : 1429 AH
2008 AD 
Article Type : Article 
Added Date : Sunday, October 11, 2009 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عبدالمعين عيد الأغاAbdulmoein E. Al-AghaResearcher  
عبدالمحسن محمد أحمدجي Abdulmohsin M. S. AhmadjeeResearcher  
بروز اتش بانيتز Bruce H. BennettsResearcher  
ألبيرت كي شان Albert K. ChanResearcher  
كيم اف دونجهوKim F. DonaghueResearcher  

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